Iran's state-run media say the government plans to build 10 new uranium enrichment plants similar to the country's main enrichment facility in Natanz.
State media report five locations have already been approved for new plants, and the country's Atomic Energy Agency has been directed to find five additional sites.
The Iranian government's announcement about expanding its controversial nuclear program comes as international powers and the United Nations nuclear agency attempt to curb Iran's enrichment activities.
White House spokesman Robert Gibbs said Iran would be committing a serious violation of its international obligations. He added that it is "another example of Iran choosing to isolate itself."
The United Nations Security Council has subjected Iran to three rounds of sanctions for its failure to halt enrichment activities.